Diversity on the distribution and drug resistance of the multiple drug resistance bacteria of our hospital from 2010 to 2011

Objective To investigate pathogen distribution and the drug resistance in patients of our hospital from 2010 to 2011.Methods From 2010 to 2011,157 multiple drug resistance bacterial were isolated from specimen of inpatients,and then the drug resistance was determined by agar disc diffusion method and all results were analyzed.Results 157 pathogens were isolated,Gram-positive bacteria amounted for 40,with Staphylococcus aureus predominated.Gram-negative bacteria amounted for 117,the distribution were Escherichia coli,Acinetobacter bauman Pseudomnnas aeruginsa,other Gram-negative bacteria,in flora vicissitude,isolating rates of the gram-negative bacteria was downturn in general;on the contrary,the gram-positive bacteria was upgraded.The difference of distribution of bacteria was significant in different time(P0.05).Escherichia coli all positive with extended sperctrum beta lactamases,were resistant to ceftazidine,but sensitive to imipenem,mild sensitive to cefoxitin: Pseudomnnas aeruginsa maintained high rate of resistance to most antibiotics.The lowest rate of drug resistance were piperacillin tazobactam.Imipenem,minocyline;Acinetobacter bauman mostly were pan drug resistance which were resistant to all antibiotics excerpt polymyxin B;Staphylococcus aureus maintained high rate sensitivity to vancomycin,undetected vancomycin-resistant enterococcus.Conclusions The glycopeptides antibiotics for gram positive bacteria,carbapenem,beta-lactam/beta lactamamase inhibitor compound drug on gram negative bacteria remain relatively antibacterial activity,but pan drug resistance Acinetobacter bauman has increasingly become new problem for anti-infection treatment in our hospital.