Comparison of intravenous propofol/remifentanil with intravenous propofol plus inhalational isoflurane in general anesthesia

Objective To study the differences between intravenous propofol/remifentanil and propofol plus inhalational isoflurane in the hemodynamic changes during intratracheal intubation and recovery of consciousness in general anesthesia and to explore the options of extubation.Methods Sixty surgical patients (ASA I～II) were randomly divided into intravenous propofol/remifentanil group (Group R) and intravenous propofol plus inhalational isoflurane group (Group C),with 30 for each.BP and HR were monitored during the induction of anesthesia,intratracheal intubation,and postoperative recovery.The time of eye opening and extubation following anesthetic discontinuation was recorded and VRS for pain assessment was performed right after extubation,on the leaving of the operation room,and at 3rd and 24th hour after surgery and the side effects of anesthetics such as nausea and vomiting were recorded.Results Hemodynamic changes within 1～5 minutes after the induction of anesthesia and intubation in Group R were significantly less than those in Group C (P 0.05).The recovery time from anesthesia was shorter and the intratracheal tube could be removed earlier in Group R (P 0.05).Less nausea or vomiting occurred in Group R whereas the grade of VRS in Group R was higher than that in Group C.Conclusions Anesthesia with intravenous propofol/remifentanil has stable hemodynamics and less complications during intratracheal intubation and can shorten the recovery time of unconsciousness and the duration of intubation.Postoperative analgesia should be performed as soon as possible.