Effect and Mechanism of Ganxiankang Decoction on Rats' Liver Fibrosis

Objective To study the inhibitory effect of Ganxiankang decoction on hepatic fibrosis induced by CCl4 in rats.Methods Liver fibrosis in rats was induced by subcutaneous injection of CCl4 and Ganxiankang decoction was administered by intragastric injection.The serum levels of alanine aminotransferase(ALT),malondialdehyde(MDA),hyaluronic acid(HA),laminin(LM) and hydroxyproline(Hyp),GSH in liver tissue were determined.And the pathogenic changes of liver tissue were also observed.Results In model group,the serum levels of ALT,MDA,HA,LM and Hyp in liver tissue were significantly increased,while liver content of GSH was markedly reduced and liver fibrosis was obviously observed.After treated Ganxiankang decoction supplemented rats,the serum levels of ALT,MDA,HA,LM and Hyp were significantly reduced,and liver content of GSH was markedly restored.Liver fibrosis was evidently attenuated.Conclusion Ganxiankang decoction was capable of attenuating liver fibrosis in rats,which might be derived from the inhibition of lipid peroxidation.