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2006•Zhongguo yaofangRequires access

Inhibitory Action of Salidrose on Hepatic Fibrosis

Yi Zhang, Yonggang Liu

Open publisher page 2 citations

Abstract

OBJECTIVE:To investigate the inhibitory action of salidrose on hepatic fibrosis of rats.METHODS:CCl 4 -induced hepatic fibrosis rat(n=55)model was built up,then were administrated low,median and high dose of salidrose positive control malotilate,and compared with normal group(n=10),the pathohistological changes were observed after6wk under light microscope and hepatic fibrosis degree was monitored before and after treatment by determining levels of ALT,AST,NO,HA and LN in serum and Hyp and MDA in liver tissue.RESULTS:Salidrose significantly reduced the elevated levels of ALT,AST,NO,HA,LN in serum and the exorbitant Hyp and MDA in liver tissue.Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.CONCLUSION:Salidrose has inhibitory action on experimental liver fibrosis to some extent.

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OBJECTIVE:To investigate the inhibitory action of salidrose on hepatic fibrosis of rats.METHODS:CCl 4 -induced hepatic fibrosis rat(n=55)model was built up,then were administrated low,median and high dose of salidrose positive control malotilate,and compared with normal group(n=10),the pathohistological changes were observed after6wk under light microscope and hepatic fibrosis degree was monitored before and after treatment by determining levels of ALT,AST,NO,HA and LN in serum and Hyp and MDA in liver tissue.RESULTS:Salidrose significantly reduced the elevated levels of ALT,AST,NO,HA,LN in serum and the exorbitant Hyp and MDA in liver tissue.Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.CONCLUSION:Salidrose has inhibitory action on experimental liver fibrosis to some extent.

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Available abstract

OBJECTIVE:To investigate the inhibitory action of salidrose on hepatic fibrosis of rats.METHODS:CCl 4 -induced hepatic fibrosis rat(n=55)model was built up,then were administrated low,median and high dose of salidrose positive control malotilate,and compared with normal group(n=10),the pathohistological changes were observed after6wk under light microscope and hepatic fibrosis degree was monitored before and after treatment by determining levels of ALT,AST,NO,HA and LN in serum and Hyp and MDA in liver tissue.RESULTS:Salidrose significantly reduced the elevated levels of ALT,AST,NO,HA,LN in serum and the exorbitant Hyp and MDA in liver tissue.Histopathologic examination also showed its significant amelioration effect on experimental liver fibrosis.CONCLUSION:Salidrose has inhibitory action on experimental liver fibrosis to some extent.

Key concepts: Fibrosis, Hepatic fibrosis, Liver fibrosis, Internal medicine, Hepatic stellate cell, Liver tissue, Medicine, Pathology

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