Clinicopathological features of cardiac primary rhabdomyosarcoma

Objective To study the clinicopathological characteristics of cardiac primary rhabdomyosarcoma and to elucidate its diagnosis and differential diagnosis. Methods Clinicopathological characteristics and immunohistochemical findings were analyzed in a case of cardiac primary rhabdomyosarcoma and related literatures were reviewed. Results The tumor was composed of big roundish and spindle cells with deep stained and pleomorphic nuclei. Tumor cells were heterogeneously diffuse. In some areas there was mucoid or pink stroma. Some cells were well differentiated and showed caryokinesis. Several egacaryocytes were visible. Nodular tumor tissue infiltrated into normal myocardium. Immunohistochemically,tumor cells were positive for PAS,S-100,desmin,vimentin,CD68,MyoD1,Ki-67 and myoglobin,and but negative for CK,CD117,and P53. 68% tumor cells were PCNA positive. Conclusions Cardiac primary rhabdomyosarcoma is rare,and high malignant and invasive. As its morphological and clinical features are heterogeneous,the immunohistochemical staining can help in the diagnosis.