Increasing the detection rate of cervical lesions of low grade by liquid-based thin-layer cytological detection

Objective:To explore the application value of liquid-based thin-layer cytological detection technology(LCT).Methods:The results of LCT from the hospital from July 2,2008 to January 16,2009 were analyzed,then the results were compared with those of routine cervical smears.Results:The positive rate of LCT(the positive cases including LSIL,HSIL,SCC,ACC,ASC,AGUS,AGC,and HPV infection) was 13.51%(104/770),44 positive cases underwent cervical biopsy,19 cases(48.18%) were found with positive results of cervical histological examination.The positive rate of routine cervical smears was 1.83%(31/1 692),22 positive cases underwent cervical biopsy,11 cases(50.00%) were found with positive results of cervical histological examination.The analysis on grouping of degrees of lesions of the positive cases showed that there was no significant difference in the total detection rate of cervical lesions of high grade(including HSIL,SCC,and ACC) between LCT(1.17%,9/770) and routine cervical smears(1.30%,22/1 692)(P0.05).The proportions of cases with cervical lesions under LSIL(including LSIL,ASC,AGUS,and HPV infection) accounted for 91.35%(95/104) in LCT positive group and 29.03 %(9/31) in routine cervical smears positive group,there was significant difference between the two groups(P0.05).The proportions of cases under forty years old accounted for 55.77% in LCT positive group and 25.81% in routine cervical smears positive group,there was significant difference between the two groups(P0.05).Conclusion:LCT technology can provide high-quality cytological smears,increase the positive rate of cervical cytological detection,especially for the young patients with cervical lesions under LSIL,LCT plays an important role in early detection and diagnosis of cervical cancer.