Chincal significance of liquid-based cytology test in the detection of cervical lesions

Objective: To evaluate the clinical significance and weakness of liquid-based cytology test (LCT) in the diagnosis of cervical lesions. Methods: From August 2006 to October 2008, 340 patients from Baoshan District Center Hospital were received LCT, and underwent cytological examination with cervical tissues under electronic colposcopy. Results: The coincidence rates of LCT with pathologic histology in LSIL, HSIL and cervical cancer were 12.16% (9/74), 57.89% (22/38) and 73.33% (11/15) respectively. Among 66 cases with ASC, 15.15% (10/66) was with CIN Ⅱ-Ⅲ, 1.51% (1/66) was with cervical cancer diagnosed pathologically. Among the 16 cases with AGC 12.55% (2/16) was with CINⅡ-Ⅲ. In the cases of cervical cancer, the predilection ages of onset showed double hump, 30-39 years old and ≥45 years old. Conclusion: As a preliminary screening method of cervical cancer, LCT may have false positive or negative results. But combined with col poscopy and multiple biopsy, LCT can improve the diagnostic accuracy of cervical lesions and be helpful in the early diag nosis and early treatment.