Expression and significance of ERCC-1 and LRP in non-small cell lung carcinoma

Objective To investigate the effect of ERCC-1 and LRP genes in the non-small cell lung carcinoma(NSCLC) and its clinical relevance.Methods The expression of ERCC-1 and LRP genes in 46 patients with NSCLC and 16 patients in normal lung tissue were studied by immunohistochemical SP methods.Results The positive expression rate of ERCC-1 and LRP in NSCLC specimens was 54.3% and 82.6%,respectively.Positive rate of ERCC-1 and LRP expression in normal lung tissue was 6.25% and 6.25%,respectively.Expression rates of ERCC-1 in pulmonary adenocarcinoma and squamous adenocarcinoma were 64.2% and 55.6%,respectively,and were significantly higher than that in squamous carcinoma(47.8%).The LRP expression was singnificantly correlated with dregree of tumor differentiation(P0.05).Conclusion The positive rate of ERCC-1 and LRP expression in NSCLC tissue was higher than that in normal lung tissue.The LRP expression was correlated with dregree of tumor differentiation.Survival period of patients with LRP positive was shorter than that with LRP negative.