2006•Journal of Wenzhou Medical CollegeRequires access

Changes of Nitriergic nerves and interstitial cell of Cajal in intestinal myen-teric plexus of diabetic rats.

Yanhua Ren

Abstract

Objective: To study the changes of nitriergic nerves and interstitial cell of Cajal(ICC) in intestinal myenteric plexus of diabetic rats.Methods: Diabetes mellitus(DM) model was established with streptozotocin(STZ) in 12 SD rats.At the same time,6 same germ line normal SD rats were established as control(C) group.Densities of nitriergic nerves and ICC were observed in duodenal myenteric plexus in two goups of rats.Results: Compared with control group,the number of nitriergic nerves and ICC were significantly decreased(P0.01) in DM group rats.Conclusion:The changes in nitriergic nerves and ICC in myenteric plexus of rat duodenum may be closely related to intestinal dysfunction.

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Key concepts: Myenteric plexus, Interstitial cell of Cajal, Internal medicine, Streptozotocin, Plexus, Duodenum, Medicine, Interstitial cell