2000•Journa of Henan Medical UniversityRequires access

Effect of sodium ferulate on the production of nitric oxide in cultured human umbilical vein endothelial cells

Lei Fu

Abstract

Aim: To study the effect of sodium ferulate (SF) on the production of nitric oxide (NO) in cultured human umbilical vein endothelial cells Methods: Effects of oxidized low density lipoprotein (OX LDL),VitE and SF to the NO level in cultured endothelial cells in human umbilical vein were individually measured by NO kits Results: OX LDL significantly decreased the level of NO in a dose and time dependent manner in cultured endothelial cells; SF and antioxidant vitamin E can significantly decrease the inhibition of OX LDL on the production of NO in cultured endothelial cells Conclusion: SF has the protective effect on cultured endothelial cells producing NO as same as the Vitamin E

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Key concepts: Umbilical vein, Nitric oxide, Chemistry, Antioxidant, Vitamin E, Vitamin C, Sodium, Sodium ascorbate