ScholarLens Back to search
2006•Fain kemikaruRequires access

An Improved Synthetic Method of Telmisartan

Huiyong Zhang

Open publisher page 2 citations

Abstract

Telmisartan was synthesized through multistep reactions with 3-methyl-4-nitrobenzoic acid as starting material.3-Methyl-4-nitrobenzoic acid via esterification,reduction,butyrylation,nitration,reduction and cyclization gave 2-n-propyl-4-methyl-6-carboxybenzimidazole,which condensed with N-methyl-o-phenylenediamine in the presence of polyphosphoric acid and followed by condensation with 4′-bromomethyl-biphenyl-2-carboxylic acid methyl ester and hydrolysis to give Telmisartan.The overall yield was improved from 20.9% to 30%.It has been produced in Henan Tianfang Phamaceutical Co.Ltd.

About this research paper

What this paper is about

Telmisartan was synthesized through multistep reactions with 3-methyl-4-nitrobenzoic acid as starting material.3-Methyl-4-nitrobenzoic acid via esterification,reduction,butyrylation,nitration,reduction and cyclization gave 2-n-propyl-4-methyl-6-carboxybenzimidazole,which condensed with N-methyl-o-phenylenediamine in the presence of polyphosphoric acid and followed by condensation with 4′-bromomethyl-biphenyl-2-carboxylic acid methyl ester and hydrolysis to give Telmisartan.The overall yield was improved from 20.9% to 30%.It has been produced in Henan Tianfang Phamaceutical Co.Ltd.

Why it matters

OpenAlex reports 2 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Telmisartan was synthesized through multistep reactions with 3-methyl-4-nitrobenzoic acid as starting material.3-Methyl-4-nitrobenzoic acid via esterification,reduction,butyrylation,nitration,reduction and cyclization gave 2-n-propyl-4-methyl-6-carboxybenzimidazole,which condensed with N-methyl-o-phenylenediamine in the presence of polyphosphoric acid and followed by condensation with 4′-bromomethyl-biphenyl-2-carboxylic acid methyl ester and hydrolysis to give Telmisartan.The overall yield was improved from 20.9% to 30%.It has been produced in Henan Tianfang Phamaceutical Co.Ltd.

Key concepts: Telmisartan, Chemistry, Yield (engineering), Hydrolysis, Nitration, Condensation, Organic chemistry, Nuclear chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
An Improved Synthetic Method of Telmisartan — Research Paper | ScholarLens