Analysis of Escherichia Coli and Klebsiella Pneumoniae Drug Sensitivity

Objective:To research the antibiotic resistance difference between Escherichia coli and Klebsiella pneumoniae strains from different specimens sources and different wards.Method:The drug susceptibility results from 802 strains of Escherichia coli and 802 strains Klebsiella pneumoniae of the Sichuan Provincial People's Hospital in 2011 were analysed by WHONET 5.5.Result:Escherichia coli experienced low antibiotic resistance rates to imipenem(0.2%),ertapenem(1.4%),cefotetan(1.8%),followed by piperacillin/tazobactam(3.0%),amikacin(4.0%),nitrofurantoin(4.5%).Low-level antibiotic resistance in Klebsiella pneumoniae were followed by imipenem(3.2%),amikacin(3.3%),cefotetan(4.9%),ertapenem(6.8%),piperacillin/hetazobactam(8.0%).ESBL-producing strains accounted for 61.8% in Escherichia coli and 35.5% in Klebsiella pneumoniae.Klebsiella pneumoniae showed low antibiotic sensitivity in urine specimens than sputum,blood and other sterile body fluids.Sensitivity of Escherichia coli and Klebsiella pneumoniae in pediatric ward was higher than medical,surgical and ICU ward.Conclusion:Escherichia coli and Klebsiella pneumoniae still maintain a high degree of sensitivity to carbapenem antibiotic,cephamycins and piperacillin-tazobactam.Escherichia coli and Klebsiella pneumoniae from different specimens sources and different ward exist different antibiotic susceptibility.The use of antibiotics in clinical treatment should be based on susceptibility results.