Expression and Meaning of VEGF-C in Oral Squamous Cell Carcinoma

Objective: To investigate the expression of vascular endothelial growth factor C(VEGF-C) in oral squamous cell carcinoma(OSCC) and adjacent tissues,and to investigate the effect of the VEGF-C in the proliferation,invasion and metastasis of OSCC.Methods: Image analysis system was used to detect the expression of VEGF-C in OSCC.Adjacent normal tissues in 60 patients were determined by immunohistochemical staining,then the relationship with lesion,size,pathologic grade,clinical stage and neck lymph node metastasis was analyzed.Results:There was significant difference between the OSCC and the adjacent tissues in the expression ofVEGF-C(u=7.747,P 0.01),which indicated there was close relation between the VEGF-C expression intensity and the proliferation,invasion and metastasis of OSCC.Conclusion: The VEGF-C expressed by OSCC plays an important role in regional lymph node metastasis by inducing Cancer-week lymphatic hyperplasia expansion.