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2012•Journal of Oral and Maxillofacial SurgeryRequires access

Expression of D2-40 and VEGF-C and Lymph Node Metastasis in Oral Squamous Cell Carcinoma

Jinying Liu

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Abstract

Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C(VEGF-C) and D2-40 are related to metastatic behavior of oral squamous cell carcinoma(OSCC).Methods: A retrospective review of 43 cases with OSCC were conducted.The cases were separated into metastasis group and non-metastasis group,in addition,10 specimen of normal oral mucosa were used as control.D2-40 and VEGF-C expression were detected by immunohistochemistry.Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery.The expression of lymphatic vessel density(LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P0.05),and they were significantly higher in lymph node metastasis group than in non-metastatic group(P0.05).Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC.

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What this paper is about

Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C(VEGF-C) and D2-40 are related to metastatic behavior of oral squamous cell carcinoma(OSCC).Methods: A retrospective review of 43 cases with OSCC were conducted.The cases were separated into metastasis group and non-metastasis group,in addition,10 specimen of normal oral mucosa were used as control.D2-40 and VEGF-C expression were detected by immunohistochemistry.Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery.The expression of lymphatic vessel density(LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P0.05),and they were significantly higher in lymph node metastasis group than in non-metastatic group(P0.05).Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC.

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Available abstract

Objective: The purpose of this study was to investigate whether the expression of vascular endothelial growth factor C(VEGF-C) and D2-40 are related to metastatic behavior of oral squamous cell carcinoma(OSCC).Methods: A retrospective review of 43 cases with OSCC were conducted.The cases were separated into metastasis group and non-metastasis group,in addition,10 specimen of normal oral mucosa were used as control.D2-40 and VEGF-C expression were detected by immunohistochemistry.Results: Lymphatic vessels in OSCC mainly distributed in the tumor periphery.The expression of lymphatic vessel density(LVD) and VEGF-C in OSCC were significantly higher than those in normal tissue(P0.05),and they were significantly higher in lymph node metastasis group than in non-metastatic group(P0.05).Conclusion: The peri-tumoral lymphatic vessels are associated with lymph node metastasis and VEGF-C may related to the generation of lymphatic vessels in OSCC.

Key concepts: Medicine, Lymphatic system, Immunohistochemistry, Lymphatic vessel, Pathology, Vascular endothelial growth factor C, Metastasis, Basal cell

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Expression of D2-40 and VEGF-C and Lymph Node Metastasis in Oral Squamous Cell Carcinoma — Research Paper | ScholarLens