Effects of ginkgolide B on glial fibrillary acidic protein expression after thrombotic cerebral ischemia in tree shrews

AIM: The present study was designed to ex amin e the changes in glial fibrillary acidic protein (GFAP) expression during cerebr al ischemia and the effects of ginkgolide B on GFAP expression. METHODS: The focal thrombotic cerebral ischemia was formed by ph otochemistry-induced in tree shrews. GFAP stained by ABC immunohistochemistry an d absorbance were measured with image analyze system. RESULTS: GFAP expression in astrocytes increased significantly ( P0.01) at 24 h and kept in higher level at 72 h (P0.01) within penu mbra after focal cerebral ischemia. GFAP expression declined when the animals we re given GB at 6 h after thrombotic cerebral ischemia. CONCLUSIONS: Neuronal necrosis resulted in GFAP expression in as tr ocytes after local cerebral ischemia and GB protected neurons by antagonizing PA F receptor and inhibiting GFAP expression.