The effect of endometrial local injury on the outcome of in vitro fertilization-embryo transfer

Objective To analyze the effect of endometrial local injury on the incidence of successful pregnancy in patients undergoing in vitro fertilization-embryo transfer (IVF-ET). Methods Two hundred and thirty-seven patients were studied who were with endometrial disorder or thickness diagnosed by ultrasound on the day of gonadotropin was used. Two hundred and twenty patients (treatment group) were operated local injury to regain normal endometrium or remove thickened endometrium at the same day of gonadotropin was used. The remaining 17 patients were not treated and used as control. The outcome of IVF- ET in the two groups was evaluated by the rates of clinical pregnancy, embryo implantation and live births. Results There were no significant differences between the two groups in the age of the patients, duration for infertility, response to hormone stimulation, the numbers of oocytes and embryo, and the rate of fertilization. However, the rates of clinical pregnancy, embryo implantation and live births in the treatment group were 52.27%, 36.56% and 45.00%, respectively, which were significantly higher than those in the control group (23.53%, 13.51% and 23.53%). Conclusion Local injury to the endometrium significantly improves the successful pregnancy in patients undergoing in vitro fertilization.