Effect of endometrial surgery with minimal damage on the outcome of in vitro fertilization with GnRH antagonists

Objective:To explore the effect of endometrial surgery with minimal damage on clinical pregnancy rate,embryo implantation rate and live birth rate of cases receiving in vitro fertilization-embryo transfer(IVF-ET) with GnRH antagonists.Methods:The patients with infertility who were treated with IVF-ET with GnRH antagonists in reproductive center of the hospital from January 2007 to December 2009 were analyzed retrospectively,B-type ultrasound showed that there were 69 patients with abnormality of endometrial echo or the depth of endometrium5 mm on the day of gonadotropin start,28 patients who were treated with endometrial surgery with minimal damage were selected as study group,and the other 41 patients who didn't receive endometrial surgery with minimal damage were selected as control group,the differences of clinical pregnancy rate,embryo implantation rate and live birth rate were compared between the two groups.Results:There was no significant difference in the average age,duration time of infertility,basic follicle-stimulating hormone(FSH) level,start dose of gonadotropin,the days of gonadotropin usage,the total dose of gonadotropin,the blood estradiol level on the day of human chorionic gonadotropin(HCG) injection,the number of retrieved oocytes,the fertilization rate,the number of embryo suitable for transfer and the number of transferred embryos between the two groups(P0.05).The clinical pregnancy rate,embryo implantation rate and live birth rate in study group were 50.00%,28.13% and 46.43%,respectively,which were higher than those in control group(41.46%,23.47% and 31.71%,respectively),but there was no significant difference(P0.05).Conclusion:Endometrial surgery with minimal damage can't improve the outcome of IVF-ET with GnRH antagonists.