A clinicopathological analysis of gastrointestinal stromal tumors in 91 cases

Objective To investigate the clinical and pathological features of gastrointestinal stromal tumors.Methods Totally 91 cases of gastrointestinal stromal tumors from January 2010 to January 2013 were retrospective analyzed.Expression of CD117,CD34,DOG1,Desmin and S-100 were determined by immunohistochemistry.Results 91 cases of patients were diagnosed as gastrointestinal stromal tumors,including 38 malignant,21 borderline and 32 benign.The expression of CD117 was positive in 79 of 91 patients with gastrointestinal stromal tumors( 86.8%),CD34 was positive in 69 of 91 patients with gastrointestinal stromal tumors( 75.8%),DOG1 was positive in 74 of 91 patients with gastrointestinal stromal tumors( 81.3%),SMA was positive in 39 of 91 patients with gastrointestinal stromal tumors( 42.9%),Desmin was positive in 15 of 91 patients with gastrointestinal stromal tumors( 16.5%),and S-100 was positive in 14 of 91 patients with gastrointestinal stromal tumors( 4.4%).Conclusion Gastrointestinal stromal tumors have more occurrence site and complex morphology,and diagnosis mainly combined with histology and immunohistochemistry.The combination of CD117,CD34 and DOG1 can can improve the diagnostic accuracy of gastrointestinal stromal tumors,and SMA,Desmin and S100 are important differential diagnostic indicators.