Study on the immunohistochemical and pathological characteristics of gastrointestinal mesenchymal tumors

Objective To study the pathological and immunohistochemical characteristics of gastrointestinal mesenchymal tumors. Methods The expressions of CD117, CD34, Vimentin, S-100, SMA and Bcl-2 were detected in 60 cases of gastrointestinal mesenchymal tumors tissues with immunohistochemistry. Results Fifty-one cases were gastrointestinal stromal tumors, 5 cases were leiomyomas and 1 case was schwannomas in 60 cases of gastrointestinal mesenchymal tumors. As to immunohistochemical reaction to GIST, the positive rate of CD117 was 90.19%, of CD34 was 80.39%, of Vimentin was 86.27%, of Bcl-2 was 74.50%, of SMA was 29.41%,and of S-100 was 11.76%.Conclusion Gastrointestinal stromal tumor is the most common mersenchymal tumor in gastrointestinal tract. To diagnose the gastrointestinal stromal tumors not only depends on microscope, but also depends on immunohistochemistry. CD117 and CD34 may be helpful in the diagnosis of gastrointestinal stromal tumors.