2000•Zhongguo bingli shengli zazhiRequires access

Effect of bFGF on expression of endothelial cell integrin beta_(1) subunits

Xulong Zhou, Yiping Deng

Abstract

AIM: To study the effect of basic fibroblast growth factor(bFGF) to the expression of integrin β 1 subunit of endothelial cells. METHOD: The expression of integrin β 1 subunit of endothelial cells was determined before and after bFGF treatment with Western Blot and immage analysis method.RESULTS: The mean gray value of immunostain by immage analysis method is 166.11±9.86 in the experimental group and 175.32±5.12 in the control group, suggested that bFGF may upregulate expression of integrin β 1 subunits of endothelial cell. CONCLUSION: bFGF may play an important role in angiogenesis by way of inducing the overexpression of endothelial cell integrin β 1 subunits.

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Key concepts: Basic fibroblast growth factor, Integrin, Angiogenesis, Western blot, Endothelial stem cell, Cell biology, G alpha subunit, Cell