Pharmacokinetic Study of Berberine Hydrochloride in Chickens

This article investigated the pharmacokinetics of berberine hydrochloride in chickens.The plasma concentration of berberine was determined by HPLC.The plasma concentration-time data of berberine hydrochloride was analyzed by Drug and Statistics(DAS).Following intravenous administration(3 mg·kg-1),the drug concentration-time data was best described by a three-compartment open model,t1/2β,t1/2γ,Vc,CL and AUC were(0.41±0.24) h,(3.66±1.06) h,(25.49±21.77)L·kg-1,(43.20±16.21)L·h-1·kg-1 and(78.92±30.58)μg·L-1·h respectively.The drug concentration-time data was best described by a two-compartment open model after oral administration of 50 mg·kg-1,t1/2α,t1/2β,t1/2ka,Tmax,Cmax and AUC were(1.87±0.76) h,(4.18±3.14) h,(0.89±0.46) h,(2.64±0.63) h,(4.09±0.11)μg·L-1 and(26.18±10.73)μg·L-1·h respectively.The absolute bioavailability was 2.03% after oral administration.Berberine hydrochloride had a low rate of bioavailability by oral administration,and its elimination was fast.