Study on Growth and Decline Changes of Maternal Antibody and Immune Antibody of AA Chicken Avian Influenza
XU Chun-hou
Abstract
XU Chun-hou
Abstract
[Objective] The study was to provide the basis for preventing AA chicken avian influenza.[Method] The 8-day old AA chicken were immunized by 2 kinds of avian influenza vaccines with different doses,andthe growth and decline changes of maternal antibody and immune antibody of AA Chicken avian influenza was studied through hemagglutination inhibition(HI)test.[Result] The maternal antibody of AA Chicken avian influenza was decreased gradually when the chicken was 1-7 days old and then it was decreased rapidly,which indicated that the half-life of the maternal antibody was about 2 d.2 kinds of avian influenza vaccines all could be used for preventive inoculation on AA chicken.After the chickens were simmunized for15 d,the titer of immune antibody HI reached the protection critical value,and it reached the peak value on the 20th d after immunization,then it was decreased gradually,but it was still above the critical value when the chickens were 43 days old.The difference of the peak values of HI antibody titer produced by vaccination with 2 kinds of avian influenza inactvaed oil-emulsion vaccines with different dosages was obviously significant.[Conclusion] The avian influenza in commercial AA chickens could be prevented under the condition of selecting avian influenza inactvaed oil-emulsion vaccine with dosage of 0.5 ml/chicken,immune time for the chicken at 8 day old of and immuning 1 time in whole feeding period.
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[Objective] The study was to provide the basis for preventing AA chicken avian influenza.[Method] The 8-day old AA chicken were immunized by 2 kinds of avian influenza vaccines with different doses,andthe growth and decline changes of maternal antibody and immune antibody of AA Chicken avian influenza was studied through hemagglutination inhibition(HI)test.[Result] The maternal antibody of AA Chicken avian influenza was decreased gradually when the chicken was 1-7 days old and then it was decreased rapidly,which indicated that the half-life of the maternal antibody was about 2 d.2 kinds of avian influenza vaccines all could be used for preventive inoculation on AA chicken.After the chickens were simmunized for15 d,the titer of immune antibody HI reached the protection critical value,and it reached the peak value on the 20th d after immunization,then it was decreased gradually,but it was still above the critical value when the chickens were 43 days old.The difference of the peak values of HI antibody titer produced by vaccination with 2 kinds of avian influenza inactvaed oil-emulsion vaccines with different dosages was obviously significant.[Conclusion] The avian influenza in commercial AA chickens could be prevented under the condition of selecting avian influenza inactvaed oil-emulsion vaccine with dosage of 0.5 ml/chicken,immune time for the chicken at 8 day old of and immuning 1 time in whole feeding period.
Key concepts: Influenza A virus subtype H5N1, Antibody, Hemagglutination assay, Antibody titer, Immune system, Titer, Biology, Vaccination