2013•Zhongguo shouyi xuebaoRequires access
Treatment effects of serum against swainsonine on rabbits poisoned by Oxytropis glabra DC
Wang Shua
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Abstract
The serological and immunological index was detected to evaluate the effects of serum against SW on rabbits poisoned by Oxytropis glabra DC.Eighteen rabbits were randomly separated into control group(6rabbits),poisoning group(6rabbits)and poisoning and curing group(6rabbits).Poisoning rabbits were fed 10g/(kg·d)power of Oxytropis glabra DC until rabbit in poisoning group was dead.On d 21after poisoning,rabbits in poisoning and curing group were treated by injecting 0.5mL serum against SW for four days.Blood samples were collected before the poisoning,and then once every 7days for indexes of serological and immunological evaluation.The result showed that the change of serum AKP and content of SW in poisoning groups were significant higher than that in control group on d 7(P0.05),the change of serum LDH and AST in poisoning groups were significant higher than that in control group on d 14(P0.05),the change of serum AMA and E-rosette in poisoning groups were significant lower than that in control group on d 14(P0.05),the change of serum BUN,CRE and GLU in poisoning groups were significant higher than that in control group on d 21(P0.05).By injecting serum against swainsonine,the change of serum AKP,LDH,AST,ALT and content of BUN,CRE,GLU,SW in poisoning and curing group was significant lower than poisoning group,the change of serum AMA and E-rosette in poisoning and curing group was significant higher than poisoning group.The results indicated that serum against SW had an offective of preventing Oxytropis glabra DC.