Curative effect analysis of sublingual immunotherapy in 62 cases of children with allergic rhinitis

Objective To evaluate the curative effect of sublingual immunotherapy in children allergic rhinitis by standardized dermatophagoides farinae allergen vaccine drops and explore the immunological mechanisms.Methods 62 cases of children with allergic rhinitis whose test result was positive for dermatophagoides farinae were divided into two groups randomly: The sublingual immunotherapy group(31 cases)which accepted standardized dermatophagoides farinae allergen a(?)ine drops sublingual immunotherapy and the control group(31 cases) which accepted antihistamine drug therapy or local nasal steroid spray.The course of treatment was two years.Evaluating the curative effect by the changes of symptoms and physical signs which were measured by VAS(visual analogue scale) and detecting the serum levels of total IgE,specific IgE levels of dermatophagoides farinae.Results The effective rate was 80.6%in the sublingual immunotherapy group,and 64.5%in the control group.Although the symptom score was statistically different after treatment in each group(P0.01 ),there was no statistical difference between the two groups(P0.05).Serum total Ig E and mite specific IgE showed no statistical difference (P0.05) before and after sublingual immunotherapy treatment.Conclusion Application of standardized dermatophagoides farinae allergen vaccine drops in allergic rhinitis sublingual immunotherapy in children with allergic rhinitis can release symptoms and reduce drugs.