Effect on Hyperammonaemia after Eradication Therapy of Helicobacter Pylori Infection in 42 Patients with Liver Cirrhosis

Objective To study the effects on hyperammonaemia after eradication therapy of Helicobacter pylori(Hp) infection in patients with liver cirrhosis. Methods Ammonia concentrations in blood were examined. Among 65 patients with liver cirrhosis,42 cases were positive of helicobacter pylori and 23 negative. The cases of Hp positive were divided into group A and B. Patients in group A were treated with anti-Hp drugs. Data of ammonia were analysed after eradication of Hp. Results Ammonia in patients with Hp positive liver cirrhosis was significantly higher than that in patients with Hp negative liver cirrhosis. Ammonia after eradication of Hp in group A was significantly lower than that in group B. Conclusion Helicobacter pylori infection could induce hyperammonia in patients with liver cirrhosis which may be one of the factors to induce hepatic encephalopathy. The eradication of helicobacter pylori is effective to lower blood ammonia in patients with liver cirrhosis hyperammonia.