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2006•Chinese Journal of PharmaceuticalsRequires access

Determination of Residual Organic Solvents in Gemfibrozil by Capillary GC with Headspace

Xin Zhang

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Abstract

A capillary GC method with headspace for determination of residual organic solvents—ethyl formate,tetrahydrofuran and methylcyclohexane in gemfibrozil was established. A HP-1 capillary column was used with N,N-dimethyl acetamide as the solvent and ethyl acetate as the internal standard. The average recoveries were 99.8%, 100.3% and 100.0%, with RSDs of 0.71%, 1.51% and 1.76%, respectively.

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What this paper is about

A capillary GC method with headspace for determination of residual organic solvents—ethyl formate,tetrahydrofuran and methylcyclohexane in gemfibrozil was established. A HP-1 capillary column was used with N,N-dimethyl acetamide as the solvent and ethyl acetate as the internal standard. The average recoveries were 99.8%, 100.3% and 100.0%, with RSDs of 0.71%, 1.51% and 1.76%, respectively.

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Available abstract

A capillary GC method with headspace for determination of residual organic solvents—ethyl formate,tetrahydrofuran and methylcyclohexane in gemfibrozil was established. A HP-1 capillary column was used with N,N-dimethyl acetamide as the solvent and ethyl acetate as the internal standard. The average recoveries were 99.8%, 100.3% and 100.0%, with RSDs of 0.71%, 1.51% and 1.76%, respectively.

Key concepts: Chemistry, Chromatography, Tetrahydrofuran, Acetamide, Ethyl acetate, Capillary action, Solvent, Capillary gas chromatography

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