Treatment of respiratory failure secondary to the acute exacerbation of chronic obstructive pulmonary diseases through bilevel positive airway pressure ventilation via nasal/mouth mask

Objective To evaluate the clinical effectiveness by using bilevel positive airway pressure(BiPAP) ventilation via nasal/mouth mask in patients with respiratory failure secondary to the acute exacerbation of chronic obstructive pulmonary diseases(COPD).Methods 35 patients were rangdomly submitted either to standard therapy plus BiPAP and 30 patients to standard therapy.Cliniacl manifestation(including respiratory rate,heart rate,blood pressure and conscious status)and arterial blood gas analysis before and after 2 hour?24hour after treatment in each group were comparatively analyed.Results After treatment by BiPAP,patients showed a significant improvement in PaO_2,PaCO_2,and clinical manifestation,and there was a significant difference between two groups(P0.05).Conclusion BiPAP ventilation is effective in patients with respiratory failure during acute exacerbation of COPD.