Treatment of Respiratory Failure Secondary to the Acute Exacerbation of COPD Through Pressure Ventilation Via Nasal/mouth Mask

Objective:To evaluate the clinical effect by using bilevel positive airway pressure(BiPAP) ventilation via nasal/mouth mask in patients with respiratory failure secondary to the acute exacerbation of chronic obstructive pulmonary disease(COPD).Method: 23 patients were randomly submitted either to standard therapy plus BiPAP and 22 patients to standard therapy.Cliniaal manifestation(including respiratory rate,heart rate,blood pressure and conscious status) and arterial blood gas analysis before and after 2 hour、 24 hour after treatment in each group were comparatively analyzed.Result: After treatment by BiPAP,patients showed a significant improvement in PaO_2,PaCO_2,and clinical manifestation,and there was a significant difference between two groups(P0.05).Conclusion: BiPAP ventilation is effective in patients with respiratory failure during acute exacerbation of COPD.