The study of TGF-β both in serum and peritoneal dialysate of rat with peritoneal fibrosis

ObjectiveTo investigate the prevention and treatment of peritoneal fibrosis in long-term peritoneal dialysis patients.MethodsThirty Wistar rats were divided into three groups,A group model group,received daily intraperitoneal injection of 20 mL 4.25%,B medicine group,received daily intraperitoneal injection of 20 mL 4.25% and angiotensin-converting enzyme inhibitor(inhibace) 10mg/kg·d was given orally to rats by gastric gavage in the morning once a day C group control group received daily intraperitoneal injection of 20 mL 0.85% natrli cloride.Thirty days late TGF-β expression were examined in abdominal cavity liquid and serum of peritoneal dialysis rats.Histopathology of parietal peritoneum was examined.ResultsTGF-β obviously increased in Both A and B groups as compared to C group(P0.05)so do histopathology of peritoneum fibrosis.Conclusionshigh glucose can induce peritoneal fibrosis the expression of TGF-βboth in abdominal cavity liquid and serum is up-regulated which is involved in the mechanism of peritoneal fibrosis,that can be inhibated by angiotensin-converting enzyme inhibitor(inhibace).Inhibace can relieve peritoneal fibrosis.