The Value of Differential Diagnosis by Serum CA19-9 between Benign and Malignant Jaundice

Objective To explore the value of differential diagnosis by serum CA19-9 combinatied with serum total bilirubin to distinguish benign and malignant obstructive jaundice.Methods 15 cases of CA19-9 above the normal of benign obstructive jaundice and 23 patients with malignant obstructive jaundice patients were monitored by the serum CA19-9 and total bilirubin before and after treatment to inuestigate the correlation of the two indexs.Results Serum CA19-9 of patients with benign obstructive jaundice significantly decreased after treatment,the difference was significant(P0.01);CA19-9 of patients with malignant obstructive jaundice was no significantly difference before and after treatment(P=0.067).There was a positive correlation between the change of CA19-9 level and serum total bilirub in patients with benign obstructive jaundice before and after treatment(r=0.92 and 0.87,P0.01).However,there was no correlation in the malignant group(r=0.12 and 0.02,P=0.64 and 0.83).Conclusion Using CA19-9 levels of benign obstructive jaundice before and after treatment in patients with a significant difference,combined with positively correlation between CA19-9 and serum total bilirubin could distinguish benign from malignant obstructive jaundice.