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Infection Status of Human Papillomavirus(HPV) Type 16 in Cervical Intraepithelial Neoplasia and Invasive Cervical Cancer

Song Hongbi

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Abstract

Objective: To investigate the infection status of human papillomavirus type 16(HPV16) in cervical intraepithelial neoplasia(CIN) and invasive cervical cancer(ICC).Methods: Immunohistochemistry(IHC)and DNA flow-through hybridization gene chip technique(HybriMax)were used to detect HPV16 in 30 CIN cases and 33 ICC cases.Results: HPV16 infection rates in total 63 cases,CIN cases and ICC cases were 34.92%(22/63),33.33%(10/30)and 36.36%(12/33) respectively tested with IHC.While these infection rates tested with HybriMax were 28.57%(18/63),23.33%(7/30)and 33.33%(11/33)respectively.Conclusions: The HPV16 infection rates in CIN and ICC cases observed in this investigation are lower than those reported from other regions,suggesting that CIN and ICC in these patients may be caused by other factors.

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What this paper is about

Objective: To investigate the infection status of human papillomavirus type 16(HPV16) in cervical intraepithelial neoplasia(CIN) and invasive cervical cancer(ICC).Methods: Immunohistochemistry(IHC)and DNA flow-through hybridization gene chip technique(HybriMax)were used to detect HPV16 in 30 CIN cases and 33 ICC cases.Results: HPV16 infection rates in total 63 cases,CIN cases and ICC cases were 34.92%(22/63),33.33%(10/30)and 36.36%(12/33) respectively tested with IHC.While these infection rates tested with HybriMax were 28.57%(18/63),23.33%(7/30)and 33.33%(11/33)respectively.Conclusions: The HPV16 infection rates in CIN and ICC cases observed in this investigation are lower than those reported from other regions,suggesting that CIN and ICC in these patients may be caused by other factors.

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Available abstract

Objective: To investigate the infection status of human papillomavirus type 16(HPV16) in cervical intraepithelial neoplasia(CIN) and invasive cervical cancer(ICC).Methods: Immunohistochemistry(IHC)and DNA flow-through hybridization gene chip technique(HybriMax)were used to detect HPV16 in 30 CIN cases and 33 ICC cases.Results: HPV16 infection rates in total 63 cases,CIN cases and ICC cases were 34.92%(22/63),33.33%(10/30)and 36.36%(12/33) respectively tested with IHC.While these infection rates tested with HybriMax were 28.57%(18/63),23.33%(7/30)and 33.33%(11/33)respectively.Conclusions: The HPV16 infection rates in CIN and ICC cases observed in this investigation are lower than those reported from other regions,suggesting that CIN and ICC in these patients may be caused by other factors.

Key concepts: Cervical intraepithelial neoplasia, Cervical cancer, Immunohistochemistry, HPV infection, Human papillomavirus, Medicine, Koilocyte, Intraepithelial neoplasia

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