Effects of Sophoridine on the Cardiac Function of Rats with AMI

Objective To investigate the effects of sophoridine on the cardiac function in rats with acute myocardial ischemia(AMI) injury.Methods The model was established by ligating the left anterior descending coronary artery(LAD).SD rats were randomly devided into eight groups: normal saline(NS) group,Sham group,AMI group,Danshen(DS) 125 mg/kg group,nitroglycerin(NTG) 0.3 mg/kg group,sophoridine(SR) 2.5,5,10 mg/kg groups.To observe and record cardiac function indexs of pre-LAD occlusion,and post-LAD occlusion at 1,5,15,30 and 60 min.The results were compared with those in NS and AMI groups.Results(1) LVSP and ±dp/dtmax were decreased significantly(P0.01),LVEDP was increased(P0.01) after LAD occlusion.(2) These results indicated that SR was able to improve LVSP and ±dp/dtmax changes and decrease LVEDP of AMI the dosages of 2.5 mg/kg,5 mg/kg and 10 mg/kg IV.Compared with sham group,the cardiac function indexes in drug groups were decreased,but they were better than those of NS group,indicating that SR was able to stabilize cardiac function during AMI injury.Conclusion Sophoridine can improve the cardiac function of acute myocardial ischemia injury rats induced by LAD acduion.