Effects of Matrine on the Hemodynamics in Rats of Acute Myocardial Ischemic Injury

Objective To study the effects of matrine on the hemodynamics in Rats of Acute Myocardial Ischemic Injury.Methods Sprague-Dawley rats were divided into eight groups,i.e.,control,sham operation,AMI,Dan- shen+AMI,nitroglycerin+AMI,AMI+MT2.5mg/kg,5mg/kg,or 10mg/kg.Rat models of AMI were created by ligation left anterior descending coronary artery.At pre-occlusion and 5,15,30,60 min after left anterior descend- ing artery (LAD) occlusion,left ventricular systolic pressure (LVSP),left ventricular end diastolic pressure (LVEDP), +dp/dtmax and-dp/dtmax were measured.Results At 5,15,30,60 min after left anterior descending artery oc- clusion,LVSP,+dp/dtmax,-dp/dtmax were reduced(P0.05 or P0.01)and LVEDP was increased signifi- candy(P0.01)in AMI group.At 5,15,30,60 min after LAD occlusion,LVSP,+dp/dtmax,-dp/dtmax were increased(P0.05 or P0.01)and LVEDP was reduced significantly(P0.05 or P0.01)in AMI rats after MT administration at the dosage of 2.5 mg/kg,5 mg/kg,10 mg/kg.At 15,30 min after LAD occlusion,this function was obvious.The more rats got matrine,the longer the changes of parameters mentioned above lasted.Conclusion Intravenous matrine can improve the cardiac function.