Correlation of human glioma angiogenesis with stromal cell derived factor-1α expression

Objective To explore the expression of stromal cell derived factor-1α(SDF-1α) in human glioma and its relationship with glioma angiogenesis. Methods Altogether 58 cases of gliomas and 18 normal brain tissues were selected for our study.The expressions of SDF-1α and CD105 were detected by immunohistochemistry,and CD105 marked microvessel density(MVD) was counted. Results Expression of SDF-1α was not found in normal brain tissues.SDF-1α marked index and CD105-MVD were closely related to the grade of glioma(P0.01).SDF-1α marked index was positively correlated with CD105-MVD(r=0.872,P0.01).SDF-1α expression and CD105-MVD were negatively correlated with patients' age,gender,and the tumor size(P0.05). Conclusion SDF-1α and CD105-MVD could serve as indexes for malignant degree of glioma.Increased expression of SDF-1α in glioma may lead to the pathogenesis and development glioma.SDF-1α may induce the tumor vessel formation by promoting the migration of vascular endothelial cells to tumor.