Analgesic Effects of Fentanyl Combined with Parecoxib on Patients after Pelvic and Lower Abdominal Surgery

Objective To compare the analgesic effects of fentanyl and parecoxib (via one bolus intravenous administration) combined with fentanyl and patient controlled intravenous analgesia (PCIA) after pelvic and lower abdominal surgery.Methods Twenty-eight patients,ASA class ⅠorⅡ,undergoing pelvic and lower abdominal surgery under general anesthesia,were randomly divided into group A (fentanyl used) and B (parecoxib combined with fentanyl used),fourteen ones per group.To treat postoperative pain,all patients received fentanyl via PCIA after surgery respectively.All the patients received postoperative visits at 4 h and 24 h respectively,meanwhile,the dose of fentanyl,using frequency of PCA (by times),VAS (visible analgesia score),and the incidence of nausea,vomiting and skin itch were recorded respectively.At the terminal of the surgery,the patients in group B was administered one bolus of parecoxib (40mg,diluted by 4ml N.S). intravenously before PCIA.Results Dose of fentanyl,times of PCA ,VAS in group B were significantly less than those in group A (P 0.05).At 4h after surgery,the incidence of nausea,vomiting and skin itch in group B was lower than that in group B respectively (P 0.05);while there was no statistical difference in incidence of nausea and vomiting between the two groups at 24 h after surgery (P 0.05).Conclusion Fentanyl combined with parecoxib is safe and effective on analgesia after lower abdominal surgery.It's worth of application in clinic.