Stability Freeze-dried Meningococcal Groups A,C,W_(135) and Y Polysaccharide Vaccine

Objective To observe the stability of freeze-dried meningococcal groups A,C,W135 and Y polysaccharide vaccine at 2～8℃.Methods Store freeze-dried meningococcal groups A,C,W135 and Y polysacchride vaccine at 2～8℃ for 30 months.Take samples periodically from the vaccine during storage for inspetion of final containers and tests for identity,polysaccharide content,molecular size,moisture content and abnomal toxicity to evaluate the stability.Results All the quality control indexes of vaccine complied with the requirements for registration of manufacturer.Conclusion Freeze-dried meningococcal groups A,C,W135 and Y polysaccharide vaccine showed good stability after storage at 2～8℃ for 30 months.