Effects of different methods of general anesthesia on postoperative cognitive dysfunction in the elderly patients

Objective To explore the influence of different methods of anesthesia on postoperative cognitive dysfunction in the elderly patients. Methods In 72 cases of elderly patients as the research object,randomly divided into three groups. Group A was given remifentanil,propofol total intravenous anesthesia. Group B received sevoflurane inhalation anesthesia. Group C received isoflurane inhalation anesthesia. Patients were adjusted the dosage of drugs according to the bispectral index value in operation,and received continuous analgesia after the operation. Record the operation time,anesthesia time,postoperative eye opening time and extubation time of three groups of patients. Compared the function of cognitive recovery of three groups before operation and the each time point( 1,3,6,24 h) after operation. Results The operation time and anesthesia time of three groups had no significant difference( P 0. 05). The postoperative eye opening time and extubation time of group B and C were significantly longer than those of group A( P 0. 05). In three groups the MMSE scores of postoperative 1 h were significantly lower than preoperative( P 0. 05). The MMSE scores of group A of postoperative3 h returned to the preoperative level,while group B was 6 h,group C was 24 h. Conclusion The total intravenous anesthesia and inhalation anesthesia in elderly patients all can cause cognitive dysfunction,but the total intravenous anesthesia can recover faster than inhalation anesthesia,and sevoflurane can recover faster than isoflurane in inhalation anesthesia.