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1998•Chinese Journal of New Drugs and Clinical RemediesRequires access

Protective effects of diazepam on cerebral ischemia-reperfusion injury in rats

Xuan Zhang

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Abstract

AIM:To study the cerebral protective effects of diazepam(Dia). METHODS:Four-vessel occlusion method was used to make acute cerebral ischemia-reperfusion model. Rats were divided into 5 groups:sham-operation,reperfusion,nimodipine 2 mg/kg,Dia 2 mg/kg and 4 mg/kg groups.Drugs were injected iv to the rats before complete ischemia,before reperfusion and during reperfusion.RUSULTS: After 40 min ischemia and 1 h reperfusion in rat brain,brain water content(BWC),brain calcium content(BCC),MDA content were elevated greatly and LDH content was decreased obviously.Dia 2 mg/kg and 4 mg/kg can reduce BWC,decrease BCC,suppress the rise of MDA,and increase LDH content. Dia improved the EEG amplitude during reperfusion and reduced the number of dead neurons.CONCLUSION: Dia has great cerebral protective effects against ischemia-reperfusion injury.

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What this paper is about

AIM:To study the cerebral protective effects of diazepam(Dia). METHODS:Four-vessel occlusion method was used to make acute cerebral ischemia-reperfusion model. Rats were divided into 5 groups:sham-operation,reperfusion,nimodipine 2 mg/kg,Dia 2 mg/kg and 4 mg/kg groups.Drugs were injected iv to the rats before complete ischemia,before reperfusion and during reperfusion.RUSULTS: After 40 min ischemia and 1 h reperfusion in rat brain,brain water content(BWC),brain calcium content(BCC),MDA content were elevated greatly and LDH content was decreased obviously.Dia 2 mg/kg and 4 mg/kg can reduce BWC,decrease BCC,suppress the rise of MDA,and increase LDH content. Dia improved the EEG amplitude during reperfusion and reduced the number of dead neurons.CONCLUSION: Dia has great cerebral protective effects against ischemia-reperfusion injury.

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Available abstract

AIM:To study the cerebral protective effects of diazepam(Dia). METHODS:Four-vessel occlusion method was used to make acute cerebral ischemia-reperfusion model. Rats were divided into 5 groups:sham-operation,reperfusion,nimodipine 2 mg/kg,Dia 2 mg/kg and 4 mg/kg groups.Drugs were injected iv to the rats before complete ischemia,before reperfusion and during reperfusion.RUSULTS: After 40 min ischemia and 1 h reperfusion in rat brain,brain water content(BWC),brain calcium content(BCC),MDA content were elevated greatly and LDH content was decreased obviously.Dia 2 mg/kg and 4 mg/kg can reduce BWC,decrease BCC,suppress the rise of MDA,and increase LDH content. Dia improved the EEG amplitude during reperfusion and reduced the number of dead neurons.CONCLUSION: Dia has great cerebral protective effects against ischemia-reperfusion injury.

Key concepts: Nimodipine, Diazepam, Ischemia, Reperfusion injury, Medicine, Anesthesia, Pharmacology, Brain ischemia

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