Expression of Serum MMP-13,TNF-α and IL-6 in Patients with Chronic Hepatitis and Liver Cirrhosis

Objective To detect serum MMP-13,TNF-α and IL-6 levels of the patients with chronic hepatitis B and liver cirrhosis,and evaluate their significant changes.To explore the correlation between serum TNF-α,IL-6 and MMP-13 levels.Method Double antibody Sandwich Enzyme-Linked Immunosorbent Assay(DAS-ELISA) was used to detect chronic hepatitis in 13 cases,Liver cirrhosis in 28 cases and MMP-13 in the 13 controls,TNF-α in the 20 controls and IL6 in the 30 controls.Results Compared with the controls and chronic hepatitis,the serum MMP-13 levels of the patients with liver cirrhosis were significantly higher;the serum TNF-α and IL-6 levels of patients with chronic hepatitis as well as liver cirrhosis were significantly higher;the serum TNF-α and IL-6 levels did not relate to serum MMP-13 in patients with chronic hepatitis and liver cirrhosis.Conclusions MMP-13 has important effect on formation of liver fibrosis.TNF-α and IL-6 have little effect on expression of MMP-13 levels of the patients with chronic hepatitis and liver cirrhosis.