Effectiveness and safety of valsartan-amlodipine tablet for hypertension: a systematic review

Objective To review effectiveness and safety of valsartan-amlodipine tablet for hypertension. Methods According to evidence-based medicine criteria,12 randomized controlled trials( including 2 796 patients) focusing on Valsartan-amlodipine tablet for the treatment of hypertension were included to perform a meta-analysis. Treatment effects were assessed using systolic blood pressures,diastolic blood pressures,the average blood pressure over 24 h,clinical effects and the incidence of adverse reactions. All data were analyzed by using Review Manager 5. 0. Results Meta-analysis results indicated that Valsartan-amlodipine tablet group had better clinical efficacy than amlodipine group( OR = 3. 36,95%CI: 2. 17 ~ 5. 19,P 0. 001),valsartan( 80 mg) group( OR = 3. 19,95% CI: 2. 40 ~ 4. 24,P 0. 001),and valsartan( 160 mg) group( OR = 1. 61,95% CI: 1. 12 ~ 2,32,P = 0. 010). Compared with amlodipine group,the incidence of adverse reactions in valsartan-amlodipine tablet group was lower( OR = 0. 45,95% CI: 0. 27 ~ 0. 74,P 0. 001),but there was no significant difference in the incidence of adverse reactions between valsartan-amlodipine tablet group and valsartan group. Conclusions Valsartan-amlodipine tablet for the treatment of hypertension is safe and effective.