Effects of gene recombining hepatitis B vaccine immunization in 1500 children

Objective To evaluate the effects of gene recombining hepatitis B vaccine after 8 years immunization.Methods The multiple stratified cluster sampling was used in this epidemiological survey.The sampling children's blood serum HBsAg,anti-HBs and anti-HBc were checked and measured by the solid phase radioimmunoassay(SPRIA).The serological levels of these indexes and the causes of the children with HBsAg positive were analyzed.Results There were 1 500 cases surveyed and the total HBsAg positive rate was 0.47%.The vaccine protective rate was 89.00%.The total anti-HBc positive rate was 2.07%.The average anti-HBs positive rate was 44.47% and it was descending following the children growing.GMT was 58.03 mIU/mL,showing no statistical significance among the age groups.Among the HBsAg positive children,57.14% of the children's mothers were HBsAg positive also.Conclusions The protective effects of gene recombining hepatitis B vaccine immunization are significant in the children for 8 years.The HBsAg positive rate does not ascend obviously as the immunization time prolonging.As the anti-HBs positive rate might be descending following the children growing,we should strengthen the serological surveillance of hepatitis B.