Clinical Analysis of the anticoagulation treatment for the patients with non-valvular atrial fibrillation complicated with ischemic stroke

Objective:To observe the effect and security of Warfarin in low intensity and Aspirin in small dose on preventing cerebral embolism for elder patients who suffer non-valvular atrial fibrillation.Methods:190 patients suffering non-valvular atrial fibrillation who are over 65 years old were divided the into 2 groups,one group took Warfarin orally by anticoagulation intensity of(INR)(1.6~2.5),and the other took Aspirin at a dose of 100mg per day.Each patient were given follow-up annually,we observe the incidence of cerebral embolism,bleeding,and gastrointestinal adverse reactions in the two groups.Results: The incidence of cerebral embolism for standard anticoagulation group is 0.70%,and that for Aspirin group is 7.41%.This difference shows a statistical significance(P0.05).No severe bleeding symptom appeared in both groups,the percentage of gastrointestinal adverse reactions is 0 and 8.33%,so there also existed a statistical significance(P0.05).Conclusion: Warfarin in standard dose treatment is more effective in preventing cerebral embolism compared with Aspirin,which is highly secure and shows no gastrointestinal adverse reactions.