Comparison of proportional assist ventilation and synchronized intermittent mandatory ventilation treating on neonates with meconium aspiration syndrome

Objective To compare the relevant clinic indicators between the proportion of assisted ventilation(PAV) and synchronized intermittent mandatory ventilation(SIMV) in neonates with meconium aspiration syndrome(MAS).Methods Thirty neonates with a diagnosis of MAS who required mechanical ventilation were divided randomly into PAV group(surported by PAV) and SIMV group(surported by SIMV).There were 15 neonates in each group.The respiratory rate(RR),heart rate(HR),Peak airway pressure(PIP),mean arterial blood pressure(MABP),mean airway pressure(MAP),minute respiratory volume(MV),tidal volume(VT),oxygenation index(OI) and arterial blood gas analysis values were observed at before ventilation,1 h,12 h,24 h,48 h after surported and 1 h before ventilator weaning.Results All the neonates have been cured.There were no statistically significant differences in the mechanical ventilation time(F = 1.425,P = 0.243),oxygen time(F = 3.057,P = 0.091),hospital stay(F = 0.148,P = 0.703) and X-ray clearance time(F = 0.315,P = 0.579) between the two groups.There were statistically significant differences in RR,MAP,PIP and VT between the every time point of two groups(all of the P 0.05).There were no statistical significant differences in HR,MABP,MV,PH and OI between the every time point of two groups(all of the P 0.05).Conclusions PAV and SIMV mode are effective to the neonates with MAS who required the ventilation.In the case to achieve the same effect,PAV can take rapid shallow breathing pattern,the smaller tidal volume,lower MAP and PIP.