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2006•Zhongguo yaofangRequires access

Preparation and Quality Control of Dilute Atropine Sulfate Eye-drops

LI Jin-shen

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Abstract

OBJECTIVE: To establish the preparation process and method of quality control of dilute atropine sulfate eye-drops.METHODS: Mixing atropine sulfate with additives in water to prepare 0.04% atropine sulfate eye-drops.And determined the content of atropine sulfate by HPLC,the system consisted of C18 column and mobile phase of acetonitrile-water (55∶45).RESULTS: The product is colorless and clearing liquid.The linear range of atropine sulfate was 10～60μg/ml(r=0.9 999).The average recovery rate was100.2%(RSD=0.95%,n=9).CONCLUSION: The preparation process of dilute atropine sulfate eye-drops is simple and the method of quality control by HPLC is reliable.

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What this paper is about

OBJECTIVE: To establish the preparation process and method of quality control of dilute atropine sulfate eye-drops.METHODS: Mixing atropine sulfate with additives in water to prepare 0.04% atropine sulfate eye-drops.And determined the content of atropine sulfate by HPLC,the system consisted of C18 column and mobile phase of acetonitrile-water (55∶45).RESULTS: The product is colorless and clearing liquid.The linear range of atropine sulfate was 10～60μg/ml(r=0.9 999).The average recovery rate was100.2%(RSD=0.95%,n=9).CONCLUSION: The preparation process of dilute atropine sulfate eye-drops is simple and the method of quality control by HPLC is reliable.

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Available abstract

OBJECTIVE: To establish the preparation process and method of quality control of dilute atropine sulfate eye-drops.METHODS: Mixing atropine sulfate with additives in water to prepare 0.04% atropine sulfate eye-drops.And determined the content of atropine sulfate by HPLC,the system consisted of C18 column and mobile phase of acetonitrile-water (55∶45).RESULTS: The product is colorless and clearing liquid.The linear range of atropine sulfate was 10～60μg/ml(r=0.9 999).The average recovery rate was100.2%(RSD=0.95%,n=9).CONCLUSION: The preparation process of dilute atropine sulfate eye-drops is simple and the method of quality control by HPLC is reliable.

Key concepts: Atropine sulfate, Atropine, Chromatography, Chemistry, Sulfate, High-performance liquid chromatography, Anesthesia, Medicine

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