The relationship between insulin-like growth factor-1 and insulin resistance

Objective: To study the ralationship between insulin-like growth factor-1(IGF-1),insulin resistance(IR) and left ventricular hypertrophy(LVH) in essential hypertension(EH).Methods: Twenty-nine essential hypertension patients,twenty-eight essential hypertension patients with left ventricular hypertrophy and twenty-one norotensive subjects were studied using echocardiography to determined left ventricular mass index(LVMI) and left ventricular diastolic function.Serum insulin-like growth factor-1,insulin levels were measured by specific radioimmunoassay and the insulin sensitive index was calculated.To apply the analysis of variance,rank sum test and linear correlation to analyse the data.Results: Essential hypertension patients had a higher level of serum insulin-like growth factor-1,insulin and had a lower insulin sensitive index than control group(85.96±35.52 ng/ml vs 130.24±28.79 ng/ml,8.92±6.46 μU/ml vs 18.08±12.05 μU/ml,-3.42±0.99 vs-4.39±0.96,P0.01);Compared with essential hypertension patients,the levels of serum insulin-like growth factor-1 and insulin were higher,in the insulin sensitive index was lower essential hypertension patients with left ventricular hypertrophy(130.24±28.79 ng/ml vs 215.79±71.73 ng/ml,18.08±12.05 μU/ml vs 25.09±16.06 μU/ml,-3.49±0.96 vs-4.80±(1.04),P0.01).There was a significantly correlation between the serum insulin-like growth factor-1 and insulin,insulin sensitive index(r=0.352 2,r=-0.363 5,P0.05).Conclusions: Study shows that serum insulin-like growth factor-1 levels increased in patients with essential hypertension,especially in those with left ventrciular hypertrophy;The essential hypertension patients and the essential hypertension patients with left ventricular hypertrophy have high levels of insulin and insulin resistance;In patients with left ventricular hypertrophy,The insulin resistance may play a role indirectly by enhance the serum insulin-like growth factor-1 levels.