Clinical efficacy of topiramate or carbamazepine in treatment of partial seizures

Objective To observe the clinical efficacy and adverse reactions of topiramate and carbamazepine in the treatment of partial seizures. Methods Eighty-five patients of partial seizures in our hospital from August 2012 to October 2013 were randomly divided into two groups in accordance with the order of admission, The control group(40 patients) was given carbamazepine treatment, while the observation group(45 patients) was given topiramate. The clinical efficacy and adverse events were compared between the two groups. Results The total effective rate of the observation group was 93.33%, significantly higher than 75.00% of the control group(χ2=7.229, P0.05). The incidence of adverse reactions in the observation group was 28.89%, significantly lower than 47.50% in the control group(χ2=6.308, P0.05). Conclusion The effect of topiramate in the treatment of partial seizures is better than carbamazepine, with fewer adverse reactions, which should be applied in clinical practice.