Effects of biejia ruangan recipe on cardiac remolding and left ventricular performance in spontaneous hypertensive rat

AIM: To investigate the effects of biejia ruangan recipe on cardiac remolding and left ventricular performance in spontaneous hypertensive rat (SHR). METHODS:12-week-old SHRs were divided randomly into 5 groups: the SHR-C group(untreated), the SHR-Y group(treated with Enalapril),the SHR-B1,the SHR-B2 and the SHR-B3 groups(treated with the low, middle and high dose of biejia ruangan recipe respectively), each group consisting of 10 rats. And 10 normal SD rats were used as the negative control. Systolic blood pressure(SBP), left ventricular end diastolic pressure(LVEDP), maximal ascending and descending velocity of the left ventricular pressure(±dp/dt max), heart mass index(HMI), left ventricular mass index(LVMI) and left ventricular collagen contents were determined after 10 weeks' treatment. RESULTS: After 10 weeks' treatment,compared with SHR-C, the SBP, HMI, LVMI of SHR-Y were significantly decreased( P0.01), but there was no difference in these parameters between SHR-C and SHR-B; the LVEDP of SHR-Y,SHR-B2 and SHR-B3 were significantly decreased( P0.01 or P0 05); the +dp/dt max of SHR-Y were increased( P0.05), but there was no difference in these parameters between SHR-C and SHR-B; the -dp/dt max of SHR-Y and SHR-B were significantly increased( P0.01 or P0.05);the left ventricular collagen contents of SHR-Y,SHR-B2 and SHR-B3 were significantly decreased( P0.01 or P0.05). CONCLUSION: Although biejia ruangan recipe has no significant effect on decreasing blood pressure, it can influence the remolding of the left ventricle and improve the function of the left ventricle by inhibiting myocardial fibrosis.