Expressions and clinical significance of CD11a and CD54 in acute leukemia

Objective:To investigate the expressions of CD11a and CD54 in acute leukemia and their clinical implications. Methods:The expressions of CD11a and CD54 in 20 cases of acute lymphoblastic leukemia (ALL), 27 cases of acute myeloid leukemia (AML) and bone marrow mononuclear cells of 16 normal controls were measured by flow cytometric analysis. Results:The expressions of CD11a and CD54 in ALL or AML patients were much lower than that in the control (P0.01). The expressions of CD11a and CD54 in ALL or AML patients with complete remission (CR) had no difference with that of the control (P 0.05). The patients without CR still showed significantly lower expressions of CD11a and CD54 than control. ALL or AML patients with extramedullary invasion showed higher expressions of CD11a and CD54 than those without extramedullary invasion (P0.01). Conclusion:The expressions of CD11a and CD54 were abnormal in acute leukemia. They could be used as helpful markers to observe therapeutic efficacy and evaluate prognosis.