Study on liver injury model induced by alcohol

Objective To establish liver injury model induced by alcohol and to study the model dynamically .Methods Kumming mice were randomly divided into seven groups.They were given 50% alcohol by gavage for1,3,5,10,30and60days.The control group was given distilled water.Livers were observed pathologically,and serum was analyzed biochemcially.Results The alcoholic fatty liver(AFL)model occurred induced by 50% alcohol for60days.Conclusion The different alcoholic liver disease phases were stimulated by 50% alcohol for different times,which could be applied in screening health foods for protecting alcohol injury.