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2013•Liaoning Zhongyiyao Daxue xuebaoRequires access

Effect of Soybean Isoflavones Active-extracts on Activities of ChAT and Caspase-3 in AD Rats

Xinhua Wang

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Abstract

Objective:To investigate the mechanism about learning and memory abilities of soybean isoflavones(SIF)on AD rat.Methods:The AD rat model was established by injecting amyl-beta protein(Aβ25-35)into the right amygdalate,observing the influence on ChAT and caspase-3 in hippocampus of AD rats by different doses of soybean isoflavones.Results:The results showed that SIF could increase activities of ChAT and reduce activities of caspase-3.Conclusion:The effect of SIF could against the injuries of the cholinergic system and apoptosis,and improve the learning and memory ability in AD rats.

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What this paper is about

Objective:To investigate the mechanism about learning and memory abilities of soybean isoflavones(SIF)on AD rat.Methods:The AD rat model was established by injecting amyl-beta protein(Aβ25-35)into the right amygdalate,observing the influence on ChAT and caspase-3 in hippocampus of AD rats by different doses of soybean isoflavones.Results:The results showed that SIF could increase activities of ChAT and reduce activities of caspase-3.Conclusion:The effect of SIF could against the injuries of the cholinergic system and apoptosis,and improve the learning and memory ability in AD rats.

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Available abstract

Objective:To investigate the mechanism about learning and memory abilities of soybean isoflavones(SIF)on AD rat.Methods:The AD rat model was established by injecting amyl-beta protein(Aβ25-35)into the right amygdalate,observing the influence on ChAT and caspase-3 in hippocampus of AD rats by different doses of soybean isoflavones.Results:The results showed that SIF could increase activities of ChAT and reduce activities of caspase-3.Conclusion:The effect of SIF could against the injuries of the cholinergic system and apoptosis,and improve the learning and memory ability in AD rats.

Key concepts: Isoflavones, Medicine, Hippocampus, Cholinergic system, Apoptosis, Cholinergic, Caspase 3, Pharmacology

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